GAinS study


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Inclusion criteria

RECRUITMENT TO THIS CATEGORY IS ONLY APPROVED VIA OXFORD GMC

  • GAinS study participants who are previously healthy individuals, with minimal or no co-morbidities or smoking history who have been admitted to intensive care with sepsis aged over 18 years but less than 50 years old due to community-acquired pneumonia and developed organ dysfunction OR
  • GAinS study participants specifically nominated as extreme responders to Sepsis for other reason

Exclusion criteria

Prior genetic testing guidance

– Results should have been reviewed for all genetic tests undertaken, including disease-relevant genes in exome sequencing data. The patient is not eligible if they have a molecular diagnosis for their condition.

– Genetic testing should continue according to routine local practice for this phenotype regardless of recruitment to the project; results of these tests must be submitted via the ‘Genetic investigations’ section of the data capture tool to allow comparison of WGS with current standard testing.

PLEASE NOTE: The sensitivity of WGS compared to current diagnostic genetic testing has not yet been established. It is therefore important that tests which are clinically indicated under local standard practice continue to be carried out.

Prior genetic testing genes

Closing statement

These requirements will be kept under continual review during the main programme and may be subject to change.

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